Ageing, Cellular Senescence and Neurodegenerative Disease

Epigenetic clock analyses of cellular senescence and ageing

A confounding aspect of biological ageing is the nature and role of senescent cells. It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are descriptions of the same phenomenon instigated by different sources, or if each of these is distinct, and how they are associated with ageing. Rece...

DNA damage, cellular senescence and organismal ageing: causal or correlative?

Cellular senescence has long been used as a cellular model for understanding mechanisms underlying the ageing process. Compelling evidence obtained in recent years demonstrate that DNA damage is a common mediator for both replicative senescence, which is triggered by telomere shortening, and premature cellular senescence induced by various stressors such as oncogenic stress and oxidative stress...

Ageing and Neurodegenerative Disorders

1Life, Health and Environmental Science Department, University of L’Aquila, 67100 L’Aquila, Italy 2Neuropsychology Unit, IRCCS Santa Lucia Foundation, 00179 Rome, Italy 3School of Life & Health Sciences, Aston University, Birmingham, West Midlands B15, UK 4Division of Behavioral Neurology, Department of Neurology and Alzheimer’s Disease Research Center, National Cheng Kung University Hospital, ...

Telomerase, senescence and ageing.

Telomeres serve to camouflage chromosome ends from the DNA damage response machinery. Telomerase activity is required to maintain telomeres. One consequence of telomere dysfunction is cellular senescence, a permanent growth arrest state. We review the key regulators of cellular senescence and recent in vivo evidence which supports p53-dependent senescence induced by short telomeres as a potent ...

Role of Neurofilaments in Ageing and Neurodegenerative Disease